MBP® News
2009.05.07

Research Results Presented by Snow Brand
at the 7th International Symposium on Nutritional Aspects of Osteoporosis

Effects of Milk Basic Protein
on RANKL+ T Cell-Mediated Bone Metabolism in Food-Sensitive Enteropathy

Snow Brand Milk Products Co., Ltd. (head office: Shinjuku, Tokyo, president: Tadaaki Kohnose) considers the research and development of leading-edge milk technologies a top priority issue and is striving towards the frontier of milk technologies.
We discovered that MBP® prevents the decrease of bone density by observing mice with food-sensitive enteropathy during joint research with the University of Tokyo.
This research result will be presented in the 7th International Symposium on Nutritional Aspects of Osteoporosis, which will be held starting on May 7th in Lausanne, Switzerland.

Details
Title : Effects of milk basic protein on RANKL+ T cell-mediated bone metabolism in food-sensitive enteropathy
Presenters : Aiko Ono, Yoshikazu Morita, and Atsushi Serizawa (Technology and Research Insutitute, Snow Brand Milk Products Co., Ltd.)
Haruyo Adachi, Hiroshi Kiyono, and Satoshi Hachimura (the University of Tokyo)
Date : May 7, 2009
Summary : Bone loss is a common feature in enteropathies caused by food antigen intake. Recent studies on enteropathies suggest that RANKL* may be responsible for bone loss. In this study, it was found that oral food antigen induced RANKL positive T cells that may contribute to bone loss in food-sensitive enteropathy. Oral co-administration of MBP® appeared to be effective in preventing food antigen-induced bone loss without affecting RANKL expression. This study showed that MBP® also helps prevent bone density reduction caused by food allergies.
* RANKL
One of the materials produced by T cells. RANKL induces differentiation of osteoclasts. Osteoclasts resorb bone (physiologically destroy bone).
Information on the Academic Meeting
7th International Symposium on Nutritional Aspects of Osteoporosis
Period : May 7th to 9th, 2009
Venue : Hotel Lausanne Palace (Lausanne, Switzerland)
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